P248: Longitudinal patterns of antidepressant usage in the context of CYP2C19 genotype among All of Us participants

Referrals were diverse: 36.5% from primary care (family medicine, internal medicine, pediatrics, and OB/GYN), 27.2% from self-referrals, 13.9% from neurology, 8.6% from rheumatology, and the remainder from other specialties.The most common referral indications included connective tissue disorders (37.5%), neurological disorders (19.4%), cancer (8.2%), and pharmacogenomic testing (6.2%). Conclusion:The PCPM Clinic's integration of genetic services within primary care has demonstrated a viable alternative service by integrating genetic services within primary care.The clinic's multidisciplinary, patient-centered approach has enabled a nuanced understanding of patient conditions through diverse genetic testing modalities.This adaptable service model highlights a practical framework that could be adopted more widely in primary care settings to expand access to routine genetic testing services and advance equitable genomic healthcare delivery.