P246: Consistent genetic loci across different case definitions of kidney stone disease: GWAS findings from the UK Biobank 500K cohort

Kidney stone disease is a prevalent condition affecting 1 in 8 Americans, posing a significant health and economic burden. Genetic influences are substantial, with heritability estimates ranging from 45% to 50%. Several genome-wide association studies (GWAS) have been conducted, but their results vary, partly due to differing definitions of kidney stone cases. This study aims to conduct three GWAS using big data from the UK Biobank, employing three different case definitions to compare the results.