P577: Decreasing disparities in inherited cancer syndromes through a systems approach: The At-Risk Cancer Genetic Syndrome Identification (ARCAGEN-ID) system
Inherited cancer-predisposing syndromes account for 3% of cancers, primarily Hereditary Breast and Ovarian Cancer Syndrome and Lynch Syndrome. Surveillance and preventive measures for diagnosed individuals facilitate early detection and appropriate treatment, ultimately reducing cancer mortality. Identifying at-risk individuals through genetic testing is crucial. Although guidelines exist to identify candidates based on personal and family cancer history, fewer than 30% of eligible individuals are currently tested, and these numbers are significantly worse among underserved populations.
Authors
- Nitu Kashyap (ORCID: https://orcid.org/0000-0001-9376-1199)
- Carolyn Haight
- Vinit Singh (ORCID: https://orcid.org/0000-0001-8428-1572)
- Andrea Pugliese (ORCID: https://orcid.org/0000-0003-4385-958X)
- A. Senna (ORCID: https://orcid.org/0000-0002-6187-6511)
- Quiana Brown
- George Chen (ORCID: https://orcid.org/0000-0002-2158-0142)
- Michelle Hughes (ORCID: https://orcid.org/0000-0003-0308-8952)
- Thomas Rafter
- Xavier Llor
- Rosa Munoz Xicola
- Jing Liu (ORCID: https://orcid.org/0000-0002-3255-3019)
Institutions
- Roswell Park Comprehensive Cancer Center (US)
- Yale New Haven Hospital (US)
- Emory University (US)
- Yale University (US)
Publication Details
- Journal
- Genetics in Medicine Open
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.gimo.2025.102425
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00