P172: A framework to identify individuals at low risk of disease in the population*
Genetics can be used to identify individuals at lower risk of disease. Benefits include (i) reallocating resources to those at increased risk, (ii) avoiding unnecessary screening, and (iii) facilitating discussions with the ‘average’ risk group about the importance of following the standard guidelines. However, few papers focus on the genetics of resistance to disease, and genetic screening programs currently do not return results for low disease risk. Concerns about misclassifying individuals at low risk have hindered implementing a ‘low genetic risk’ program.
Authors
- Natalie Telis (ORCID: https://orcid.org/0000-0002-4813-6893)
- Christopher Chapman (ORCID: https://orcid.org/0000-0003-1848-1490)
- Douglas Stoller (ORCID: https://orcid.org/0000-0002-4064-4324)
- Kelly M. Schiabor Barrett (ORCID: https://orcid.org/0000-0001-6194-787X)
- Alexandre Bolze (ORCID: https://orcid.org/0000-0001-7399-2766)
- Matthew E. Levy (ORCID: https://orcid.org/0000-0002-2164-1726)
- Joseph J. Grzymski (ORCID: https://orcid.org/0000-0003-2646-8958)
- Daniel Philip Judge (ORCID: https://orcid.org/0000-0002-3407-0248)
- C. Anwar A. Chahal (ORCID: https://orcid.org/0000-0001-7825-8827)
- Elizabeth T. Cirulli (ORCID: https://orcid.org/0000-0001-7808-2809)
- Cassie Hajek
- William Lee (ORCID: https://orcid.org/0000-0001-9582-4413)
- Douglas A. Olson
- Jeremy Cauwels (ORCID: https://orcid.org/0000-0001-5175-1902)
Institutions
- St. Luke's University Health Network (US)
- Sanford Health (US)
- University of Nevada, Reno (US)
- Medical University of South Carolina (US)
- WellSpan Health (US)
- WellSpan Ephrata Community Hospital (US)
- Helix (United States) (US)
- HealthPartners (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Genetics in Medicine Open
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.gimo.2025.102137
- Primary Topic
- Chronic Disease Management Strategies
- Type
- article
- Field-Weighted Citation Impact
- 0.00