P305: CHEK2 and pediatric cancer predisposition

Cell cycle checkpoint kinase 2 (CHK2) plays a role in cell cycle arrest, which is activated in response to DNA damage. Variants in the CHEK2 gene are autosomal dominantly inherited, and historically have been associated with adult-onset cancer predisposition, particularly low to moderate risk breast cancer (20%-40%). As such, pediatric oncology patients and their siblings are not frequently tested for mutations in this gene, and therefore, less is known about the role it plays in pediatric cancer predisposition.