P069: Progressive neurological symptoms in a 36-year-old female: Clinical challenge

At that time, the patient was in status epilepticus and was receiving several medications known to be toxic to mitochondria, including valproate, propofol, and linezolid. We recommended discontinuing those three medications specifically, which helped control her seizures the following day. To support mitochondrial function, she was started on supplements that serve as mitochondrial antioxidants and enhance Complex I function, though their effectiveness remains uncertain. She was admitted to inpatient rehabilitation for comprehensive interventional therapies directed at preserving daily functioning.

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Publication Details

Journal
Genetics in Medicine Open
Published
2025-01-01
DOI
https://doi.org/10.1016/j.gimo.2025.102913
Primary Topic
Dermatological and Skeletal Disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

P069: Progressive neurological symptoms in a 36-year-old female: Clinical challenge

Pongtawat Lertwilaiwittaya, Caterina Abdala Villa, Anna Hurst, Farah Salman
Genetics in Medicine Open
Dermatological and Skeletal Disorders
article

P069: Progressive neurological symptoms in a 36-year-old female: Clinical challenge

Pongtawat Lertwilaiwittaya, Caterina Abdala Villa, Anna Hurst, Farah Salman
article en

Abstract

At that time, the patient was in status epilepticus and was receiving several medications known to be toxic to mitochondria, including valproate, propofol, and linezolid. We recommended discontinuing those three medications specifically, which helped control her seizures the following day. To support mitochondrial function, she was started on supplements that serve as mitochondrial antioxidants and enhance Complex I function, though their effectiveness remains uncertain. She was admitted to inpatient rehabilitation for comprehensive interventional therapies directed at preserving daily functioning.

Genetics in Medicine OpenVol. 3
University of Alabama at Birmingham (US)
Gender equality
Openalex Percentile: Top 94%
Dermatological and Skeletal Disorders
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P069: Progressive neurological symptoms in a 36-year-old female: Clinical challenge — Pongtawat Lertwilaiwittaya, Caterina Abdala Villa, et al. · Genetics in Medicine Open (2025) | TGRS Research Map | TGRS