P069: Progressive neurological symptoms in a 36-year-old female: Clinical challenge
At that time, the patient was in status epilepticus and was receiving several medications known to be toxic to mitochondria, including valproate, propofol, and linezolid. We recommended discontinuing those three medications specifically, which helped control her seizures the following day. To support mitochondrial function, she was started on supplements that serve as mitochondrial antioxidants and enhance Complex I function, though their effectiveness remains uncertain. She was admitted to inpatient rehabilitation for comprehensive interventional therapies directed at preserving daily functioning.
Authors
- Pongtawat Lertwilaiwittaya (ORCID: https://orcid.org/0000-0002-8808-3829)
- Caterina Abdala Villa (ORCID: https://orcid.org/0000-0001-7338-6619)
- Anna Hurst (ORCID: https://orcid.org/0000-0002-9765-9703)
- Farah Salman
Institutions
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Genetics in Medicine Open
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.gimo.2025.102913
- Primary Topic
- Dermatological and Skeletal Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00