Exploring the Therapeutic Potential of Natural Alkaloids Against Covid-19: A Tripartite Investigation of Their Efficacy Through In-Vivo, In-Vitro and In-Silico Models

Background: In recent times, the world has been experiencing the worst outbreak of Coronavirus disease 2019 (CONVID-19), a highly contagious disease which originated in Wuhan, China, and has had a global socioeconomic and health impact. Evidence from folkloric medicine show that the disease caused by coronavirus SARS-CoV-2 has been treated traditionally while recent advances in sciences show that many vaccines have been produced, tested, approved and used to prevent the spread and contamination of CONVID-19, some alongside vaccine boosters. Method: Therefore, as a matter of urgency, there is need to discover especially from natural sources, safer, efficient and little or no side effect drugs which can inhibit CONVID protein target as well as viral enzyme replication such as 3CLpro and PLpro. This research focuses on alkaloids with possible anti-CONVID-19 activity. Some of these compounds have demonstrated high in-vitro, in-vivo and in-silico antiviral activity against the recent COVID-19 pandemic. Results: A total of 21 alkaloids, isolated between 2000 and 2020 were investigated and reviewed as possible multi-target drugs for the treatment of this disease. Conclusion: The discovery of drugs for the treatment of this disease should therefore be prioritized to drugs from natural sources. Lead drug molecules could be designed from in vivo studies, clinical trials as well as SAR analyses to effectively develop novel drug candidates against CONVID-19.