P540: Diversity of Brazilian ancestry in 3 cohorts: Challenges and insights for precision medicine*
Genetic diversity plays a critical role in understanding complex diseases, and the calculation of Polygenic Risk Scores (PRS) is heavily influenced by ancestry background. Brazilian populations exhibit a unique admixed ancestry composition due to centuries of immigration and social integration. While numerous studies have investigated Brazilian genetic ancestry, only a few have undertaken comprehensive analyses using genome sequencing.
Authors
- José Roberto Filassi (ORCID: https://orcid.org/0000-0002-1192-4220)
- Rosimeire Aparecida Roela
- Jaqueline Wang
- Fernando Marcon Passos
- Manuel Castro Carneiro (ORCID: https://orcid.org/0000-0002-4645-8266)
- Maria Lúcia Hirata Katayama (ORCID: https://orcid.org/0000-0002-2672-8222)
- Roberto R. Lima (ORCID: https://orcid.org/0009-0008-9026-016X)
- Ângela Francisca Trinconi (ORCID: https://orcid.org/0000-0002-6951-3969)
- Fernando Gallucci
- Guilherme Lopes Yamamoto (ORCID: https://orcid.org/0000-0002-0490-8257)
- Flávia Paiva Proença Lobo Lopes (ORCID: https://orcid.org/0000-0002-6713-4041)
- Laura Testa (ORCID: https://orcid.org/0000-0001-6080-7429)
- Luciane Sussuchi da Silva (ORCID: https://orcid.org/0000-0002-7470-4655)
- Marcelo Imbroinise Bittencourt (ORCID: https://orcid.org/0000-0003-1206-9489)
- Raphael Bruno Amemiya
- Ivana Núñez (ORCID: https://orcid.org/0000-0003-4067-546X)
- Fernanda Erthal (ORCID: https://orcid.org/0000-0002-6172-6986)
- Eduardo Gomes Lima (ORCID: https://orcid.org/0000-0001-8501-9867)
- Simone Maistro (ORCID: https://orcid.org/0000-0002-0937-2391)
- Makoto Koike (ORCID: https://orcid.org/0000-0003-2386-5560)
- Roger Chammas (ORCID: https://orcid.org/0000-0003-0342-8726)
- Cristovam Scapulatempo‐Neto (ORCID: https://orcid.org/0000-0002-8920-6579)
- Alberto Nogueira da Gama Antunes (ORCID: https://orcid.org/0000-0003-4554-7440)
- William Carlos Nahas
- Marianna Deway Andrade Dracoulakis (ORCID: https://orcid.org/0000-0001-5521-5955)
- José Pontes
- Márcia Cristina Lopes
- Tânia Vaz
- Roberto Caldeira Cury
- Vinicius Marques Rocha
- Vinicius Sousa Flores
- Vitória Pelegrino do Val
- Felipe Aristides Simão Neto
- Ricardo Di Lazzaro
Institutions
- Human Genome Sciences (United States) (US)
- Instituto do Câncer do Estado de São Paulo (BR)
- Faculdade de Ciências Médicas da Santa Casa de São Paulo (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- DASA (Brazil)
Publication Details
- Journal
- Genetics in Medicine Open
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.gimo.2025.102383
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00