P054: Targeting KV10.1 channels in breast cancer: The role of ion channel genetics in in silico electrophysiological mechanisms and drug discovery

Ion channel genetics has emerged as a critical area of study in cancer biology, revealing significant contributions of ion channels to tumor progression. Among these, the voltage-gated potassium channel KV10.1 (Eag1) is increasingly recognized for its oncogenic role in breast cancer. KV10.1 overexpression in breast cancer cells is associated with enhanced motility, unchecked proliferation, and apoptosis resistance—processes vital to tumor growth and metastasis. Furthermore, KV10.1 has been implicated in the epithelial-to-mesenchymal transition (EMT), a hallmark of cancer metastasis, and in modulating immune interactions within the tumor microenvironment.