SET7 lysine methyltransferase mediates the up-regulation of NADPH oxidase expression, oxidative stress, and NLRP3 inflammasome priming in atherosclerosis
The novel results show that SET7 regulates important mechanisms leading to enhanced formation of reactive oxygen species and pro-inflammatory cytokines release in atherosclerosis. The data recommend SET7 as a promising target for pharmacological interventions and as supportive therapeutic strategy in atherosclerotic cardiovascular diseases.
Authors
- Alexandra-Gela Lazar (ORCID: https://orcid.org/0000-0002-2751-4744)
- Horia Mureşian (ORCID: https://orcid.org/0000-0002-1165-7142)
- Maya Simionescu (ORCID: https://orcid.org/0000-0003-2077-0400)
- Simona‐Adriana Manea (ORCID: https://orcid.org/0000-0001-5755-5494)
- Adrian Manea (ORCID: https://orcid.org/0000-0002-8795-3095)
- Mihaela-Loredana Vlad
Institutions
- Clinical Emergency Hospital Bucharest (RO)
- Romanian Academy (RO)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1186/s12967-025-06338-0
- Citations
- 7
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Ministerul Cercetării, Inovării şi Digitalizării