Subclinical left ventricular dysfunction assessed by global longitudinal strain correlates with mild cognitive impairment in hypertensive patients
Prevention of dementia represents a public health priority. Hypertension is a risk factor for mild cognitive impairment (MCI), a precursor to progressive dementia. A great effort is underway to develop accurate and sensitive tools to detect the MCI condition in hypertensive patients. To investigate the potential association of subclinical left ventricular dysfunction expressed by the global longitudinal strain (GLS) with the MCI, defined by the Italian version of the quick mild cognitive impairment (Qmci-I). This multi-centric study included 180 consecutive hypertensive patients without medical diseases and/or drugs with known significant effects on cognition but with a not negligible comorbidity burden to avoid a possible "hyper-normality bias". The study cohort was classified into two main groups concerning the median value of the GLS. A weighted logistic regression model was employed after an inverse probability of treatment weighting (IPTW) analysis to characterize a potential association between GLS and MCI. Almost 41,1% of the whole study population was female. The mean age was 65,6 ± 7,2. 39 patients (21,7%) showed MCI. After IPTW, the GLS was significantly associated with the study endpoint (OR, 1,22; 95% CI: 1,07-1,39, P = 0.003). Our results highlight that the GLS is a potential predictor of MCI and, therefore, a valuable tool for establishing preventive strategies to arrest the progression toward a cognitive decline in hypertensive patients.
Authors
- William Molloy
- Cristina Gatto (ORCID: https://orcid.org/0000-0003-1658-8470)
- Guido Iaccarino (ORCID: https://orcid.org/0000-0002-8997-835X)
- Gaetano Santulli (ORCID: https://orcid.org/0000-0001-7231-375X)
- Valeria Visco (ORCID: https://orcid.org/0000-0002-2197-5355)
- Giuseppe Dattilo (ORCID: https://orcid.org/0000-0002-6681-0183)
- Daniele Masarone (ORCID: https://orcid.org/0000-0002-6781-7424)
- Pietro Mazzeo (ORCID: https://orcid.org/0000-0002-4683-4639)
- Maddalena Illario (ORCID: https://orcid.org/0000-0001-9834-6517)
- Alfonso Campanile (ORCID: https://orcid.org/0000-0001-7002-3556)
- Germano Junior Ferruzzi (ORCID: https://orcid.org/0000-0001-9410-6321)
- Rodolfo Citro (ORCID: https://orcid.org/0000-0002-7796-6298)
- Albino Carrizzo (ORCID: https://orcid.org/0000-0003-2689-0008)
- Pasquale Mone (ORCID: https://orcid.org/0000-0001-6267-5845)
- Amelia Ravera
- Costantino Mancusi (ORCID: https://orcid.org/0000-0001-6690-1408)
- Eugenio Stabile (ORCID: https://orcid.org/0000-0001-9125-8813)
- Francesco Loria (ORCID: https://orcid.org/0000-0002-6615-3662)
- Carmine Vecchione (ORCID: https://orcid.org/0000-0002-2473-4565)
- Ilaria Fucile (ORCID: https://orcid.org/0000-0002-8507-269X)
- Luigi Falco (ORCID: https://orcid.org/0009-0005-5669-574X)
- Giancarlo Agnelli (ORCID: https://orcid.org/0000-0002-4308-7797)
- Michele Ciccarelli
- Alice Moncada (ORCID: https://orcid.org/0009-0007-4159-6014)
Institutions
- University of Messina (IT)
- University of Molise (IT)
- Albert Einstein College of Medicine (US)
- University of Salerno (IT)
- University College Cork (IE)
- Istituto Neurologico Mediterraneo (IT)
- Mercy University Hospital (IE)
- Federico II University Hospital (IT)
- St. Finbarr's Hospital (IE)
- Casa di cura Pierangeli (IT)
- Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Hypertension Research
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1038/s41440-025-02182-3
- Citations
- 7
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 9.72