Next-Generation Antifungal Therapy: Miconazole Nitrate-Loaded Microspheres for Prolonged and Enhanced Drug Action

The current research focused on developing and characterizing sustained-releasemicrospheres of miconazole nitrate (MCN) with different polymers to optimize drugentrapment efficiency and manage drug release. Microspheres were produced with anoptimized method and examined for particle size, surface topography, yield percentage,drug content, entrapment efficiency, and in vitro drug release kinetic. Optical microscopyand scanning electron microscopy (SEM) validated the spherical microspheres with a sizeof 140–210 µm. The entrapment efficiency of the drug ranged from 72.06 ± 6.09 to 89.45± 5.18 %, and the percentage yield was between 72.09 ± 5.22 and 92.60 ± 7.76 %. The invitro dissolution studies revealed sustained drug release over 12 h, with cumulativerelease percentages of 81.80 ± 8.43 to 93.60 ± 8.77 %.