Poly(ectoine)‐Based Adhesive Hydrogel with Antimicrobial and Anti‐Inflammatory Properties for Wound Treatment

Abstract Hydrogel wound dressings are appealing for managing injuries due to their multifunctional properties. The adhesive nature allows them to cover complex wound shapes, stop bleeding quickly, and eliminate the need for invasive procedures. However, their adhesion can be compromised by water molecules from wound exudates. Furthermore, bacterial infection and inflammation remain common challenges in wound healing. Herein, a poly(ectoine)‐based adhesive hydrogel with remarkable wet adhesion, antimicrobial, and anti‐inflammatory properties for wound treatment is reported. Poly(ectoine methacrylate) (PEMA) exhibits strong water absorption, effectively removing the interfacial hydration layer to promote the binding of catechol groups to substrates. The incorporation of ectoine methacrylate and dopamine imparts anti‐inflammatory capabilities, while the Jelleine‐I antimicrobial peptide ( J–I AMP) integrated into the hydrogel's main chain offers long‐lasting antibacterial effects. In vitro and in vivo tests demonstrate that this multifunctional hydrogel dressing holds potential for promoting wound healing.