Estimating the Burden of False Positives and Implementation Costs From Adding Multiple Single Cancer Tests or a Single Multi‐Cancer Test to Standard‐Of‐Care Screening
A screening system for average-risk individuals using multiple SCED tests has a higher rate of false positives and associated costs compared with a single MCED test. A set of SCED tests with the same sensitivity as standard-of-care screening detects only modestly more cancers than an MCED test limited to the same set of cancers.
Authors
- Christina A. Clarke (ORCID: https://orcid.org/0000-0002-7515-2549)
- Allan Hackshaw (ORCID: https://orcid.org/0000-0002-5570-5070)
- Earl Hubbell (ORCID: https://orcid.org/0000-0001-7301-3759)
- Sarina Madhavan (ORCID: https://orcid.org/0000-0003-3027-606X)
- Ellen T. Chang (ORCID: https://orcid.org/0000-0002-7169-157X)
Institutions
- Massachusetts General Hospital (US)
- Menlo School (US)
- Grail (United States) (US)
- University College London (GB)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/cam4.70776
- Citations
- 2
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 2.09