Empty Spiracles Homeobox 2 Transcription Factor Functions as a Tumor Suppressor in Renal Cell Carcinoma by Targeting CADM1
The EMX2-CADM1 transcriptional axis offers a promising therapeutic target for inducing cell death and inhibiting growth and invasion in RCC, which could lead to more effective treatment strategies for this aggressive malignancy.
Authors
- Tao Liu (ORCID: https://orcid.org/0000-0001-8569-7692)
- Kai Dong (ORCID: https://orcid.org/0000-0002-4715-1469)
- Juan Li (ORCID: https://orcid.org/0000-0002-3244-009X)
- Zhibin Fu (ORCID: https://orcid.org/0000-0002-0803-7890)
- Bianhong Zhang (ORCID: https://orcid.org/0000-0002-8669-2495)
- Wenqi Chen (ORCID: https://orcid.org/0000-0001-8057-4378)
- Ethan Lee (ORCID: https://orcid.org/0000-0001-8405-6156)
- Linhui Wang (ORCID: https://orcid.org/0000-0002-4056-0462)
- Lei Li (ORCID: https://orcid.org/0000-0002-3114-1653)
- Tao P. Zhong (ORCID: https://orcid.org/0000-0003-1159-5487)
- Di Gu (ORCID: https://orcid.org/0000-0003-0304-5960)
- Yuying Lan
- Chenghua Yang (ORCID: https://orcid.org/0009-0007-8653-5389)
Institutions
- Second Military Medical University (CN)
- Vanderbilt University (US)
- Shanghai Changzheng Hospital (CN)
- Changhai Hospital (CN)
- Shanghai Cell Therapy Research Institute (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Molecular Cancer Research
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1158/1541-7786.mcr-24-0496
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.00