Lipid juggling: Any1 scrambles membranes for endosome biogenesis
Multivesicular bodies (MVBs) are crucial for membrane protein degradation and lipid homeostasis. A recent study by Gao and colleagues (https://doi.org/10.1083/jcb.202410013) identifies Any1 as a phospholipid scramblase that plays an important role in MVB biogenesis by coordinating membrane remodeling with lipid transfer through Vps13 at organelle contact sites.
Authors
- David Teis (ORCID: https://orcid.org/0000-0002-8181-0253)
- Sinead Schwabl (ORCID: https://orcid.org/0000-0003-2006-4696)
- Konstantin Adrian Siegmann
Institutions
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1083/jcb.202502158
- Citations
- 1
- Primary Topic
- Cellular transport and secretion
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Austrian Science Fund