Activated T Cells Break Tumor Immunosuppression by Macrophage Reeducation
In this study, we show a mechanism whereby T-cell activation controls the innate immune system and shapes the tumor microenvironment by reducing PGD2 production in TAMs. We suggest HPGDS inhibition as a promising strategy to treat refractory tumors to current immunotherapies or to overcome acquired resistance to immune checkpoint blockade.
Authors
- Massimiliano Mazzone (ORCID: https://orcid.org/0000-0001-8824-4015)
- Oliver Edgar Bechter (ORCID: https://orcid.org/0000-0003-0667-3284)
- Jean‐Christophe Marine (ORCID: https://orcid.org/0000-0003-2433-9837)
- Jonas Dehairs (ORCID: https://orcid.org/0000-0002-6789-2264)
- Silvia Rivis (ORCID: https://orcid.org/0000-0002-0521-5751)
- Johannes V. Swinnen (ORCID: https://orcid.org/0000-0002-7720-5077)
- Francesca M. Bosisio (ORCID: https://orcid.org/0000-0002-8874-2003)
- Rosa Trotta
- Shikang Zhao (ORCID: https://orcid.org/0000-0003-2202-2510)
- Sarah Trusso Cafarello (ORCID: https://orcid.org/0000-0002-2138-1821)
- Veerle Boecxstaens (ORCID: https://orcid.org/0000-0001-5238-2619)
- Joanna Poźniak (ORCID: https://orcid.org/0000-0001-5739-1098)
- Marie‐Pauline Orban (ORCID: https://orcid.org/0000-0002-5086-382X)
- Lotte Vanheer (ORCID: https://orcid.org/0000-0003-1427-6131)
- Iris Charatsidou (ORCID: https://orcid.org/0000-0002-8156-7724)
- Carlos A. Pulido Vicuna (ORCID: https://orcid.org/0000-0001-5049-6997)
Institutions
- Humanitas University (IT)
- Universitair Ziekenhuis Leuven (BE)
- VIB-KU Leuven Center for Cancer Biology (BE)
- IRCCS Humanitas Research Hospital (IT)
- KU Leuven (BE)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-0415
- Citations
- 12
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 12.54