Comparative analysis of the inflammatory response of human gingival fibroblasts to NeoSEALER Flo and CeraSeal bioceramic sealers: an in vitro study
The study indicates that both NeoSEALER Flo and CeraSeal bioceramic sealers activate HGFs inflammatory response with a slight preference for CeraSeal biocompatibility. Therefore, it becomes important and relevant to assess the cytotoxic and inflammatory propensity of various endodontic materials in order to guide enrolment of these endodontic products in clinical practice and improve the quality of endodontic treatment. Subsequent in vivo works should be done to confirm these in vitro findings as well as to examine the chronic effects of sealer-tissue interaction.
Authors
- Sarah Salah Gaafar (ORCID: https://orcid.org/0009-0000-1237-8009)
- Mohammad Rayyan (ORCID: https://orcid.org/0000-0002-4005-6362)
- Doaa Gamal Basta (ORCID: https://orcid.org/0000-0002-1101-8199)
- Rehab Ali Farag (ORCID: https://orcid.org/0009-0008-7230-2522)
- Mohamed H. A. Gadelmawla (ORCID: https://orcid.org/0000-0002-1976-9480)
- Mohamed Sayed (ORCID: https://orcid.org/0000-0002-1491-5688)
- Ahmad Mostafa Hussein (ORCID: https://orcid.org/0000-0002-8156-3221)
- Abdel Rahman O. El Mekkawi (ORCID: https://orcid.org/0000-0002-7383-2233)
Institutions
- Sinai University (EG)
- Misr University for Science and Technology (EG)
- Mansoura University (EG)
- Nahda University (EG)
- Dar Al Uloom University (SA)
- Ahram Canadian University (EG)
- Alexandria University (EG)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1186/s12903-025-05692-1
- Citations
- 3
- Primary Topic
- Endodontics and Root Canal Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.37