Polymorphisms of PPARα and ACTN3 Among Adolescent Egyptian Athletes: A Case–Control Study

This study identified a statistically significant increase in the frequencies of the ACTN3 'R' allele (77.5% compared to 55.9%; <i>p</i> < 0.001) and the PPARα 'C' allele (86.4% compared to 14.1%; <i>p</i> < 0.001) among athletes relative to the control groups. A similar pattern was noted for adolescent athletes in comparison to the control group in terms of both the R/R genotype (61.9% compared to 27.3%; <i>p</i> < 0.001) and the C/C genotype (80.5% compared to 2.7%; <i>p</i> < 0.001). In conclusion, these results imply that polymorphisms in ACTN3 and PPARα could be significant predictors for assessing the performance of adolescent Egyptian athletes.