Broussoflavonol B induces S-phase arrest and apoptosis in pancreatic cancer cells by modulating the cell cycle checkpoint through inhibition of the AURKA/PLK1 pathway
Bf-B might be a potent therapeutic agent for pancreatic cancer because of its ability to suppress the expression of AURKA/PLK1.
Authors
- Tanveer Ali (ORCID: https://orcid.org/0000-0002-6377-0673)
- HyonSu Jo (ORCID: https://orcid.org/0000-0003-4791-2173)
- Kaiyue Ding
- Lin Zhang (ORCID: https://orcid.org/0000-0002-3767-0249)
- Lingzhi Li (ORCID: https://orcid.org/0000-0001-9119-7133)
- Zhihao Zhao (ORCID: https://orcid.org/0009-0002-3092-7985)
- Jianhua Huang (ORCID: https://orcid.org/0000-0001-5033-9545)
- Yutong Yang (ORCID: https://orcid.org/0009-0006-5266-4126)
- Zhen Wang (ORCID: https://orcid.org/0000-0003-0227-5537)
- Dong Shang (ORCID: https://orcid.org/0000-0002-4300-359X)
- Junnan Ma
- HyonU Pak
- HyokChol Choe
Institutions
- Shenyang Pharmaceutical University (CN)
- Dalian Medical University (CN)
- Korean Academy of Science and Technology (KR)
- First Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1186/s12935-025-03717-x
- Citations
- 3
- Primary Topic
- Bioactive natural compounds
- Type
- article
- Field-Weighted Citation Impact
- 2.42