Liver-FDG-uptake augments early PET/CT prognostic value for CD19-targeted CAR-T cell therapy in diffuse large B cell lymphoma
Additionally to PET30 metabolic remission, longitudinal metabolic changes in Delta-Liver-SUV<sub>mean</sub> predicted CAR-T efficiency. Our results may guide early intervention studies aiming to enhance CAR-T particularly in the very high-risk patients.
Authors
- Marion Subklewe (ORCID: https://orcid.org/0000-0001-9154-9469)
- D. Hellwig (ORCID: https://orcid.org/0000-0002-3056-0143)
- Ralph A. Bundschuh (ORCID: https://orcid.org/0000-0001-7291-9372)
- Dennis Christoph Harrer (ORCID: https://orcid.org/0000-0001-7512-572X)
- Fabian Müller (ORCID: https://orcid.org/0000-0001-5487-5839)
- Veit Bücklein (ORCID: https://orcid.org/0000-0001-7391-7280)
- Michael Winkelmann (ORCID: https://orcid.org/0000-0003-4655-7341)
- Klaus Hirschbühl (ORCID: https://orcid.org/0000-0002-4847-7460)
- Johannes Jung
- Judith S. Hecker (ORCID: https://orcid.org/0000-0002-1531-0517)
- Viktoria Blumenberg (ORCID: https://orcid.org/0000-0003-1379-0876)
- Rainer Claus (ORCID: https://orcid.org/0000-0003-2617-8766)
- Leo Hansmann (ORCID: https://orcid.org/0000-0003-3790-0128)
- Wolfgang G. Kunz (ORCID: https://orcid.org/0000-0002-5021-1952)
- Igor Yakushev (ORCID: https://orcid.org/0000-0003-4764-798X)
- Karin Menhart (ORCID: https://orcid.org/0000-0002-4529-7819)
- Simon Völkl (ORCID: https://orcid.org/0000-0003-2193-3048)
- Torsten Kuwert (ORCID: https://orcid.org/0000-0001-5682-8139)
- Andréas Mackensen (ORCID: https://orcid.org/0000-0002-0685-4483)
- Markus Eckstein (ORCID: https://orcid.org/0000-0001-5418-3349)
- Michael Beck (ORCID: https://orcid.org/0000-0003-2523-6266)
- Anna Lena Illert
Institutions
- Harvard University (US)
- University of Augsburg (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University Hospital Augsburg (DE)
- LMU Klinikum (DE)
- University Hospital Regensburg (DE)
- Massachusetts General Hospital (US)
- Universitätsklinikum Erlangen (DE)
- Comprehensive Cancer Center Erlangen (DE)
- University Hospital Carl Gustav Carus (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Technical University of Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1186/s13550-025-01201-1
- Citations
- 3
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Universitätsklinikum Erlangen