Post-treatment transmissibility of Plasmodium falciparum infections: an observational cohort study
A single course of low-dose primaquine (PQ) given with ACT significantly decreases the prevalence of gametocytaemia. Furthermore, membrane-feeding assays show that this combination also considerably lowers mosquito infection, confirming existing knowledge and emphasizing the promise of low-dose PQ as a successful transmission-blocking strategy in managing malaria.
Authors
- Hallelujah Getachew
- Ming‐Chieh Lee (ORCID: https://orcid.org/0000-0002-2462-6089)
- James W. Kazura (ORCID: https://orcid.org/0000-0002-6390-634X)
- Xiaoming Wang (ORCID: https://orcid.org/0000-0003-1232-3125)
- Guiyun Yan (ORCID: https://orcid.org/0000-0001-8760-2925)
- Ashenafi Abossie
- Christopher L. King (ORCID: https://orcid.org/0000-0003-3873-7860)
- Kassahun Habtamu
- Solomon Kibret (ORCID: https://orcid.org/0000-0003-1793-6908)
- Delenasaw Yewhalaw (ORCID: https://orcid.org/0000-0002-2907-9360)
- Daibin Zhong (ORCID: https://orcid.org/0000-0002-2771-9598)
- Assalif Demissew (ORCID: https://orcid.org/0000-0001-7054-0641)
- Beyene Petros
- Arega Tsegaye (ORCID: https://orcid.org/0000-0002-7985-9701)
- Teshome Degefa (ORCID: https://orcid.org/0000-0002-3518-2372)
- Guofa Zhou (ORCID: https://orcid.org/0000-0001-9283-5520)
Institutions
- Jimma University (ET)
- University of California, Irvine (US)
- Ambo University (ET)
- Center for Global Health (US)
- American Mosquito Control Association (US)
- Arba Minch University (ET)
- Addis Ababa University (ET)
- Case Western Reserve University (US)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1186/s12936-025-05279-9
- Citations
- 4
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 7.51
Funders
- Jimma University
- Addis Ababa University
- National Institutes of Health
- University of California, Irvine