Trends in the Incidence of Cancer Among Adolescents and Young Adults Between 2000 and 2020: A Study Based on French Population-Based Registry Data

<b><i>Purpose:</i></b> The recent rise in the incidence of cancer in younger adults has been described in high-income countries. This study aimed to identify cancer incidence trends in France among adolescent and young adult (AYA) population. <b><i>Methods:</i></b> All cases of cancer diagnosed in 15-39 years, recorded by all French population-based registries (24% of the population), over the 2000-2020 period, were included. World age-standardized incidence rates (ASR) and annual percentage change (APC) of incidence over time were calculated. <b><i>Results:</i></b> We analyzed 54,735 cancer diagnoses in AYAs. The ASR over the 2000-2020 period in 15-39 years was 58.1 per 100,000 (95% confidence interval [CI] 57.0-59.2). ASR was lower in males (47.2 [45.7-48.6]) than in females (68.9 [67.2-70.6]). Incidence per 100,000 differed with age group from the lowest, 20.5 (19.8-21.2) in 15-19 years, to the highest, 130.3 (128.6-132.0) in 35-39 years. Increases in incidence were observed for essential thrombocythemia (APC: 3.33% [1.52-5.16]), Hodgkin lymphoma (HL) (APC: 1.86% [1.21-2.52]), liposarcoma (APC: 3.68% [0.83-6.61]), carcinomas of urinary tract (APC: 3.95% [2.85-5.06]), gastrointestinal tract (APC: 2.62% [1.96-3.28]), and breast (APC: 1.61% [1.22-2.01]) from 2000 to 2020, glioblastoma (APC: 6.11% [3.06-9.26]), and other astrocytomas (APC: 7.41% [5.13-9.75]) from 2005 to 2020. Decreases in incidence were observed for oligodendroglioma (APC: -8.78% during 2005-2020), and other invasive carcinomas (APC: -3.34% during 2000-2020). <b><i>Conclusion:</i></b> Increases in the incidence of some AYA cancer types are observed HL, liposarcoma, carcinomas of colorectum, breast, and kidney. Results for central nervous system tumors are still to be confirmed in the years to come. Extensive efforts are needed to identify underlying risk factors responsible for these trends to inform prevention strategies.

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Publication Details

Journal
Journal of Adolescent and Young Adult Oncology
Published
2025-03-17
DOI
https://doi.org/10.1089/jayao.2024.0136
Citations
5
Primary Topic
Childhood Cancer Survivors' Quality of Life
Type
article
Field-Weighted Citation Impact
17.47
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article

Trends in the Incidence of Cancer Among Adolescents and Young Adults Between 2000 and 2020: A Study Based on French Population-Based Registry Data

Isabelle Baldi, Gaëlle Coureau, Perrine Marec‐Bérard, O. Ganry et al.
5 citations
Journal of Adolescent and Young Adult Oncology
Childhood Cancer Survivors' Quality of Life
17.47
article

Trends in the Incidence of Cancer Among Adolescents and Young Adults Between 2000 and 2020: A Study Based on French Population-Based Registry Data

Isabelle Baldi, Gaëlle Coureau, Perrine Marec‐Bérard, O. Ganry, Guy Launoy, Karima Hammas, Laëtitia Daubisse‐Marliac, Florence Molinié, Thomas Systchenko, Nicolas Vigneron, Emmanuel Désandes, Jacqueline Clavel, Xavier Troussard, Anne Cowppli‐Bony, Vincent Démaret, Alain Monnereau, Simona Bara, Anne-Sophie Woronoff, Brigitte Lacour, Patricia Delafosse, Michel Velten, Brigitte Trétarre, Florent Huré-Papaïconomou
article en
5 citations

Abstract

<b><i>Purpose:</i></b> The recent rise in the incidence of cancer in younger adults has been described in high-income countries. This study aimed to identify cancer incidence trends in France among adolescent and young adult (AYA) population. <b><i>Methods:</i></b> All cases of cancer diagnosed in 15-39 years, recorded by all French population-based registries (24% of the population), over the 2000-2020 period, were included. World age-standardized incidence rates (ASR) and annual percentage change (APC) of incidence over time were calculated. <b><i>Results:</i></b> We analyzed 54,735 cancer diagnoses in AYAs. The ASR over the 2000-2020 period in 15-39 years was 58.1 per 100,000 (95% confidence interval [CI] 57.0-59.2). ASR was lower in males (47.2 [45.7-48.6]) than in females (68.9 [67.2-70.6]). Incidence per 100,000 differed with age group from the lowest, 20.5 (19.8-21.2) in 15-19 years, to the highest, 130.3 (128.6-132.0) in 35-39 years. Increases in incidence were observed for essential thrombocythemia (APC: 3.33% [1.52-5.16]), Hodgkin lymphoma (HL) (APC: 1.86% [1.21-2.52]), liposarcoma (APC: 3.68% [0.83-6.61]), carcinomas of urinary tract (APC: 3.95% [2.85-5.06]), gastrointestinal tract (APC: 2.62% [1.96-3.28]), and breast (APC: 1.61% [1.22-2.01]) from 2000 to 2020, glioblastoma (APC: 6.11% [3.06-9.26]), and other astrocytomas (APC: 7.41% [5.13-9.75]) from 2005 to 2020. Decreases in incidence were observed for oligodendroglioma (APC: -8.78% during 2005-2020), and other invasive carcinomas (APC: -3.34% during 2000-2020). <b><i>Conclusion:</i></b> Increases in the incidence of some AYA cancer types are observed HL, liposarcoma, carcinomas of colorectum, breast, and kidney. Results for central nervous system tumors are still to be confirmed in the years to come. Extensive efforts are needed to identify underlying risk factors responsible for these trends to inform prevention strategies.

Journal of Adolescent and Young Adult OncologyVol. 14(6)
Délégation Paris 5 (FR), Université Toulouse III - Paul Sabatier (FR), Université de Bordeaux (FR), Inserm (FR), Université Paris Cité (FR), Centre Hospitalier Universitaire de Besançon (FR), Institut d’Hématologie et d’Oncologie Pédiatrique (FR), Sorbonne Paris Cité (FR), Santé Publique France (FR), Assistance Publique – Hôpitaux de Paris (FR), Bordeaux Population Health (FR), Registre général des cancers de Lille et de sa région (FR), Conseil Régional de Basse-Normandie (FR), CEA Le Ripault (FR), Centre François Baclesse (FR), Conseil Régional de Nouvelle-Aquitaine (FR), IMT Atlantique (FR), Institut Claudius Regaud (FR), Institut Bergonié (FR), Génomique Fonctionnelle des Tumeurs Solides (FR), Hôpital Universitaire Dupuytren (FR), Centre Hospitalier Public du Cotentin (FR), Groupe Hospitalier de la Région de Mulhouse et Sud Alsace (FR), Hôpital Paul-Brousse (FR), Centre de Recherche Épidémiologie et Statistique (FR), Lantiq (Germany) (DE)
Good health and well-being
Openalex Percentile: Top 1%
Childhood Cancer Survivors' Quality of Life
17.47
DOISourceOpenAlex
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