Fibroblast activities are associated with prolonged QTc and pulmonary arterial hypertension in patients with systemic sclerosis
Patients with SSc and prolonged QTc, presence of PAH and high NYHA class presented an altered tissue turnover, particularly associated with increased fibroblast activation. Our study indicates that serum-based biomarkers could serve as convenient biomarkers of subtle cardiac disease in SSc but further studies are needed to confirm this.
Authors
- Anne‐Christine Bay‐Jensen (ORCID: https://orcid.org/0000-0001-7952-9297)
- Axel Cosmus Pyndt Diederichsen (ORCID: https://orcid.org/0000-0002-1285-4826)
- Signe Holm Nielsen (ORCID: https://orcid.org/0000-0002-4612-1014)
- Louise Pyndt Diederichsen (ORCID: https://orcid.org/0000-0002-2581-8912)
- Jens Peter Bonde (ORCID: https://orcid.org/0000-0002-8181-3673)
- Christoffer Tandrup Nielsen (ORCID: https://orcid.org/0000-0001-7550-2994)
- M.A. Karsdal (ORCID: https://orcid.org/0000-0001-5026-8740)
- Sine Søndergaard Korsholm (ORCID: https://orcid.org/0000-0003-3947-9111)
Institutions
- Odense University Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Nordic Bioscience (Denmark) (DK)
Publication Details
- Journal
- Clinical and Experimental Rheumatology
- Published
- 2024-08-08
- DOI
- https://doi.org/10.55563/clinexprheumatol/7didmb
- Citations
- 1
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Innovationsfonden