Synthesis of Novel Vanillic Acid Hybrid Derivative

Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is a dihydroxybenzoic acid derivative used as a flavoring agent. It is used in the synthesis of various active pharmaceutical ingredients such as Etamivan, Modecainide, Brovanexine, Vanitiolide, Vanyldisulfamide etc. In this paper, novel ester / hybrid derivative of vanillic acid was synthesized. This combinatorial synthesis of novel vanallic ester / hybrid derivative can be a useful approach to generate potent chemotherapeutic agents in developing new drug candidates.