Immunotherapy-Related Sialadenitis

Sialadenitis is an inflammation of one or more of the salivary glands. A 21-year-old genetic female undergoing combination ipilimumab/nivolumab therapy for metastatic melanoma presented to our hospital with anterior neck swelling. CT imaging demonstrated bilateral submandibular gland sialadenitis. The clinical picture was most consistent with immunotherapy-related sialadenitis, and the patient responded promptly to systemic corticosteroids.