Mitochondrial FIS1 level in cumulus cells correlates with morphological grades of human cleavage-stage embryos
Mitochondrial morphology, fission-fusion balance, and fission-fusion gene expression in CCs influence early embryonic development, independent of age. Of these factors, the FIS1 level shows the most robust correlation with GQER.
Authors
- Yizhen Sima
- Yongning Lu (ORCID: https://orcid.org/0000-0001-7172-9913)
- Sanbao Shi
- Zhunyuan Min
- Hongying Sha (ORCID: https://orcid.org/0000-0003-3027-9180)
- Suying Liu (ORCID: https://orcid.org/0000-0002-3148-2247)
- Yuning Chen (ORCID: https://orcid.org/0009-0007-4010-2756)
Institutions
- Fudan University (CN)
- Zhongshan Hospital (CN)
- State Key Laboratory of Medical Neurobiology
Publication Details
- Journal
- Journal of Assisted Reproduction and Genetics
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1007/s10815-025-03431-7
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shanghai Medical College, Fudan University
- Science and Technology Innovation Plan Of Shanghai Science and Technology Commission