Study on the Modulation of NLRP1 by Natural Products in Neurodegenerative Diseases

Neuronal pyroptosis is one of the crucial pathogenesis of neurodegenerative diseases, and the signaling pathway mediated by inflammasome is the main pathway of pyroptosis. Neuroinflammation is not only a common feature, but also an essential basis for the diagnosis of neurodegenerative diseases. Neuroinflammation is an important pathological feature of common nervous system diseases such as Alzheimer's disease (AD), and Parkinson's disease (PD). NLRP1 inflammasome plays an important role in activating pyroptosis and inducing inflammatory response, so the development of drugs targeting the regulation of NLRP1 inflammasome has become a reasonable research direction for the treatment of nervous system diseases. By analyzing the current research progress of the NLRP1 inflammasome which affects the process of neuronal pyroptosis and the development of related Chinese medicine, natural products were docked with NLRP1 targets to find higher activity. The natural products and NLRP1 target were docked by CB-Dock molecular docking platform. Molecular docking results showed that silibinin, crocin, and hyperoside had excellent binding affinity, and which were the most promising potential active compounds for the treatment of AD by regulating NLRP1. This paper discusses the feasibility and rationality of the NLRP1 inflammasome as an important target for Chinese medicine research on neurodegenerative diseases in the future.