Mitochondrial fatty acid oxidation as the target for blocking therapy-resistance and inhibiting tumor recurrence: The proof-of-principle model demonstrated for ovarian cancer cells
This study revealed an upregulation of FAO in paclitaxel-tolerant ovarian cancer persister cells and provided a prospective paclitaxel-ST1326 combination therapy targeting persister cells that may prevent the development of acquired drug resistance and achieve superior long-term ovarian cancer control in the future. Our research established a conceptual framework for advancing personalized treatment approaches and enhancing patient outcomes in ovarian cancer therapy.
Authors
- Hanwen Chen (ORCID: https://orcid.org/0000-0002-4871-8789)
- Hui‐Yi Lin (ORCID: https://orcid.org/0000-0002-3307-5549)
- Dajing Xia (ORCID: https://orcid.org/0000-0001-8304-6861)
- Yihua Wu (ORCID: https://orcid.org/0000-0001-7952-4090)
- Yite Xue (ORCID: https://orcid.org/0000-0001-6180-4326)
- Conghui Wang (ORCID: https://orcid.org/0000-0001-7774-097X)
- Xiaodong Cheng (ORCID: https://orcid.org/0000-0002-6073-7261)
- Lingfang Wang (ORCID: https://orcid.org/0000-0002-9002-3657)
- Zhi‐Ming Zheng (ORCID: https://orcid.org/0000-0001-5547-7912)
- Yuqing Shen (ORCID: https://orcid.org/0000-0003-2552-4882)
- Xiao Li (ORCID: https://orcid.org/0000-0002-9358-1136)
- Yanan Zhang (ORCID: https://orcid.org/0000-0001-8274-2566)
- Hui Wang (ORCID: https://orcid.org/0000-0002-8706-2217)
- Junfen Xu (ORCID: https://orcid.org/0000-0002-2377-0775)
- Weiguo Lü
- Fenfen Wang (ORCID: https://orcid.org/0000-0002-8270-8656)
Institutions
- Peking University (CN)
- Peking University People's Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1016/j.jare.2025.03.026
- Citations
- 4
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.75
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- National Key Research and Development Program of China