The Effect of Immobilization Method on DNA Stretching Characteristics

The problem of stretching a flexible polymer molecule with specified conditions at the ends under the action of a fixed force is considered. A mathematical model has been constructed for various energy functions describing the elasticity of the polymer and various immobilization methods. It is shown that the dependence of stretching on the length of the polymer is linear. The results of numerical calculations are presented. The results obtained make it possible to improve the analysis of experimental data on polymer stretching. The theory provides several verifiable predictions, including experimental methods that improve the accuracy of measurements.

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Publication Details

Journal
BIOPHYSICS
Published
2024-12-01
DOI
https://doi.org/10.1134/s0006350924701070
Primary Topic
DNA and Nucleic Acid Chemistry
Type
article
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article

The Effect of Immobilization Method on DNA Stretching Characteristics

M. A. Didin
BIOPHYSICS
DNA and Nucleic Acid Chemistry
article

The Effect of Immobilization Method on DNA Stretching Characteristics

M. A. Didin
article en

Abstract

The problem of stretching a flexible polymer molecule with specified conditions at the ends under the action of a fixed force is considered. A mathematical model has been constructed for various energy functions describing the elasticity of the polymer and various immobilization methods. It is shown that the dependence of stretching on the length of the polymer is linear. The results of numerical calculations are presented. The results obtained make it possible to improve the analysis of experimental data on polymer stretching. The theory provides several verifiable predictions, including experimental methods that improve the accuracy of measurements.

BIOPHYSICSVol. 69(6)
Moscow Institute of Physics and Technology (RU)
Decent work and economic growth
Openalex Percentile: Top 77%
DNA and Nucleic Acid Chemistry
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