Fatal Crossroads: D-penicillamine and Disseminated Intravascular Coagulation in Wilson’s Disease

A 13-year-old male with Wilson's disease presented with progressive edema, jaundice, and neuropsychiatric symptoms. His evaluation revealed advanced hepatic dysfunction (Child-Pugh Class C), confirmed by biochemical, imaging, and histopathological findings. Despite initial stabilization, he was readmitted with acute gastrointestinal bleeding, hypotension, and laboratory evidence of disseminated intravascular coagulation (DIC), which rapidly progressed despite aggressive management. This case underscores the potential risk of DIC with D-penicillamine in Wilson's disease and highlights the need for vigilance, early recognition, and consideration of alternative treatments in susceptible patients.

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Journal
Cureus
Published
2025-03-17
DOI
https://doi.org/10.7759/cureus.80726
Primary Topic
Trace Elements in Health
Type
article
Field-Weighted Citation Impact
0.00
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article

Fatal Crossroads: D-penicillamine and Disseminated Intravascular Coagulation in Wilson’s Disease

Mariam Abdelkader, Ubaid Hashmi, Hamza Haj Mohamad, Mahasin Shaheen et al.
Cureus
Trace Elements in Health
article

Fatal Crossroads: D-penicillamine and Disseminated Intravascular Coagulation in Wilson’s Disease

Mariam Abdelkader, Ubaid Hashmi, Hamza Haj Mohamad, Mahasin Shaheen, Razan Mando, Amna Alketbi, Mohammed Alzebari, Dhuha Ali Eledresi
article en

Abstract

A 13-year-old male with Wilson's disease presented with progressive edema, jaundice, and neuropsychiatric symptoms. His evaluation revealed advanced hepatic dysfunction (Child-Pugh Class C), confirmed by biochemical, imaging, and histopathological findings. Despite initial stabilization, he was readmitted with acute gastrointestinal bleeding, hypotension, and laboratory evidence of disseminated intravascular coagulation (DIC), which rapidly progressed despite aggressive management. This case underscores the potential risk of DIC with D-penicillamine in Wilson's disease and highlights the need for vigilance, early recognition, and consideration of alternative treatments in susceptible patients.

CureusVol. 17(3)
Oasis Hospital (AE), Shaikh Khalifa Medical City (AE), University of Sharjah (AE), Mohammed Bin Rashid University of Medicine and Health Sciences (AE)
Zero hunger
Openalex Percentile: Top 94%
Trace Elements in Health
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Fatal Crossroads: D-penicillamine and Disseminated Intravascular Coagulation in Wilson’s Disease — Mariam Abdelkader, Ubaid Hashmi, et al. · Cureus (2025) | TGRS Research Map | TGRS