Multidisciplinary Tumor Board Evaluation of Pediatric Patients with Adrenocortical Tumors Across Seven International Centers
This study represents the first case-based analysis of international inter-center agreement on pediatric ACC management. Inter-center agreement regarding treatment allocation and sequencing was low, while the level of consensus within each MTB was high. These findings point to potentially significant and clinically relevant differences in treatment standards across centers, highlighting the need for international collaboration and standardized diagnostic and therapeutic recommendations, especially for rare tumors. Increased case-based exchanges between centers are essential to reduce the substantial discrepancies observed here and to further standardize the management of pediatric patients with ACC.
Authors
- Rajni Sharma
- Bilgehan Yalçın (ORCID: https://orcid.org/0000-0003-2840-0308)
- Melis Gültekin (ORCID: https://orcid.org/0000-0002-1806-2619)
- Manisha Jana
- Martin Faßnacht (ORCID: https://orcid.org/0000-0001-6170-6398)
- Jagdish Prasad Meena (ORCID: https://orcid.org/0000-0001-6024-9762)
- Jaydira Del Rivero (ORCID: https://orcid.org/0000-0001-9710-4030)
- Vishesh Jain (ORCID: https://orcid.org/0000-0002-9273-097X)
- Gerdi Tuli (ORCID: https://orcid.org/0000-0001-5862-8958)
- Jessica Munarin (ORCID: https://orcid.org/0000-0002-5075-8448)
- Dıclehan Orhan (ORCID: https://orcid.org/0000-0003-3637-5392)
- Maria Riedmeier (ORCID: https://orcid.org/0000-0002-3273-1794)
- E. Nazlı Gönç (ORCID: https://orcid.org/0000-0003-1385-2563)
- Maria Candida Barisson Villares Fragoso
- Dominika Januś (ORCID: https://orcid.org/0000-0002-3870-368X)
- Verena Wiegering (ORCID: https://orcid.org/0000-0002-2802-4034)
- Shipra Agarwal (ORCID: https://orcid.org/0000-0001-7037-4444)
- Ahitagni Biswas (ORCID: https://orcid.org/0000-0002-3453-5340)
- Saniye Ekinci (ORCID: https://orcid.org/0000-0002-2961-7069)
- Mithat Haliloğlu (ORCID: https://orcid.org/0000-0002-8502-2422)
- Wiebke Schlötelburg
Institutions
- Jagiellonian University (PL)
- National Institutes of Health (US)
- Universidade de São Paulo (BR)
- University of Würzburg (DE)
- Instituto do Câncer do Estado de São Paulo (BR)
- Comprehensive Cancer Center Mainfranken (DE)
- Universitätsklinikum Würzburg (DE)
- Ospedale Regina Margherita (IT)
- National Cancer Institute (US)
- Center for Cancer Research (US)
- The US Oncology Network (US)
- University of Turin (IT)
- All India Institute of Medical Sciences (IN)
- Hacettepe University (TR)
Publication Details
- Journal
- Cancers
- Published
- 2025-03-17
- DOI
- https://doi.org/10.3390/cancers17061014
- Citations
- 1
- Primary Topic
- Adrenal and Paraganglionic Tumors
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Deutsche Forschungsgemeinschaft