Deficiency of Adenosine Deaminase 2 Masquerading as Behçet’s Disease: Phenotypic Mimicry with HLA-B*51 Positivity
These findings highlight the broad clinical spectrum of DADA2, which can resemble BD, and suggest that HLA-B*51 positivity in DADA2 may further complicate diagnosis. Clinicians should maintain a high index of suspicion for DADA2 in early-onset BD-like cases, particularly without uveitis, or a family history of similar symptoms. Further studies are warranted to explore HLA-B*51 role in DADA2 phenotype.
Authors
- Abdulrahman Alrasheed (ORCID: https://orcid.org/0000-0001-9626-1931)
- Wafaa Alsuwairi (ORCID: https://orcid.org/0009-0002-2477-1021)
- Jubran Alqanatish (ORCID: https://orcid.org/0000-0001-6467-6972)
- Reem Alharbi (ORCID: https://orcid.org/0000-0003-3888-7850)
- Abdullah I. Almojali (ORCID: https://orcid.org/0000-0003-4208-4196)
- Fayhan Alroqi (ORCID: https://orcid.org/0000-0001-5271-0002)
- Bushra Alharbi (ORCID: https://orcid.org/0009-0004-7196-7267)
Institutions
- King Saud bin Abdulaziz University for Health Sciences (SA)
- King Abdulaziz Medical City (SA)
- King Abdullah International Medical Research Center (SA)
- King Abdulaziz Hospital (SA)
- King Abdullah Medical City (SA)
Publication Details
- Journal
- Journal of Clinical Immunology
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1007/s10875-025-01876-0
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- King Abdullah International Medical Research Center