Brønsted Acid Ionic-Liquid-Catalyzed Facile One-Pot Synthesis of 1-[(1,3-Benzothiazol-2-ylamino)methyl]-2-naphthols in a Green Medium

Abstract A rapid, simple, and efficient one-pot protocol has been developed for the sustainable synthesis of 1-[(1,3-benzothiazol-2-ylamino)methyl]-2-naphthols from substituted 2-aminobenzothiazoles, aryl aldehydes, and 2-naphthol by using 5 mol% of a Bronsted acid ionic liquid as a catalyst. This method offers several advantages such as a broad substrate scope, short reaction time, one-pot procedure, benign medium, and a high yield using a low catalyst loading. Moreover, the ionic liquid catalyst can be recycled up to three times without a noteworthy loss in catalytic activity.