Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer’s disease
Our findings suggest that αSyn co-pathology, detectable via CSF-based SAAs, is more prevalent in advanced AD and contributes to the development of aggregated tau pathology thereby driving faster cognitive decline. This highlights that a-Syn co-pathology may specifically accelerate amyloid-driven tau pathophysiology in AD, underscoring the need to consider αSyn in AD research and treatment strategies.
Authors
- Alexander Bernhardt (ORCID: https://orcid.org/0000-0002-2572-5062)
- Amir Dehsarvi (ORCID: https://orcid.org/0000-0001-7116-9741)
- Rik Ossenkoppele (ORCID: https://orcid.org/0000-0003-1584-7477)
- Anna Dewenter (ORCID: https://orcid.org/0000-0002-5636-196X)
- Anna Steward (ORCID: https://orcid.org/0000-0002-8438-3760)
- Fabian Wagner (ORCID: https://orcid.org/0000-0002-3088-0702)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Carla Palleis (ORCID: https://orcid.org/0000-0002-4331-8145)
- Matthias Brendel (ORCID: https://orcid.org/0000-0002-9247-2843)
- Johannes Gnörich (ORCID: https://orcid.org/0000-0003-1554-7765)
- Sebastian Niclas Roemer (ORCID: https://orcid.org/0000-0003-3423-457X)
- Fabian Hirsch (ORCID: https://orcid.org/0000-0002-5370-4031)
- Günter U. Höglinger (ORCID: https://orcid.org/0000-0001-7587-6187)
- Zeyu Zhu (ORCID: https://orcid.org/0000-0003-0970-4832)
- Michael Schöll (ORCID: https://orcid.org/0000-0001-7800-1781)
- Lukas Frontzkowski (ORCID: https://orcid.org/0000-0001-9321-956X)
- Nicolai Franzmeier (ORCID: https://orcid.org/0000-0001-9736-2283)
- Davina Biel (ORCID: https://orcid.org/0000-0002-2597-1992)
- Hannah de Bruin (ORCID: https://orcid.org/0000-0002-9011-1120)
- Felix Strübing
- Julia Pescoller
Institutions
- Lund University (SE)
- Sahlgrenska University Hospital (SE)
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Amsterdam Neuroscience (NL)
- Munich Cluster for Systems Neurology (DE)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Ludwig-Maximilians-Universität München (DE)
- Vrije Universiteit Amsterdam (NL)
- University of Gothenburg (SE)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s13024-025-00822-3
- Citations
- 32
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 36.09
Funders
- Alzheimer's Association
- BrightFocus Foundation
- Alzheimer's Disease Neuroimaging Initiative
- Göteborgs Universitet
- Parkinsonfonden