Fractionation of nanosecond pulsed electric fields lowers lethal dose by enhancing cardiomyocyte membrane permeability
Fractionated nsPEF improves cardiac ablation efficiency by enhancing membrane permeability and cell-killing effect. These findings suggest that fractionated delivery could optimize nsPEF therapies, offering a more effective approach for cardiac ablation.
Authors
- David Heinzmann (ORCID: https://orcid.org/0000-0003-1419-6801)
- Aleksander Kiełbik (ORCID: https://orcid.org/0000-0001-6828-6138)
- Oliver Borst (ORCID: https://orcid.org/0000-0003-4002-4085)
- Pamela W. Sowa (ORCID: https://orcid.org/0000-0002-9086-160X)
- Vitalij Novickij (ORCID: https://orcid.org/0000-0001-6147-956X)
- Meinrad Gawaz (ORCID: https://orcid.org/0000-0003-1124-9592)
- Ferdinand Kollotzek (ORCID: https://orcid.org/0000-0002-6715-064X)
Institutions
- Vilnius Gediminas Technical University (LT)
- State Research Institute Centre for Innovative Medicine (LT)
- University Children's Hospital Tübingen (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Heart Rhythm
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1016/j.hrthm.2025.03.1954
- Citations
- 6
- Primary Topic
- Microbial Inactivation Methods
- Type
- article
- Field-Weighted Citation Impact
- 7.40