Impact of metformin on HBV replication: No evidence of suppression in vitro
In HepAD38 cells, HBV replication is not impacted by metformin treatment. This contrasts with prior in vitro data but is in line with clinical evidence that suggests metformin acts through an influence on liver disease progression rather than a direct antiviral impact on HBV itself.
Authors
- Christine J. Hawkins (ORCID: https://orcid.org/0000-0001-8120-1071)
- Philippa Clare Matthews (ORCID: https://orcid.org/0000-0002-4036-4269)
- Marion Delphin (ORCID: https://orcid.org/0000-0003-0166-2367)
- Elizabeth Waddilove (ORCID: https://orcid.org/0000-0003-3228-3845)
Institutions
- The Francis Crick Institute (GB)
- University College London (GB)
Publication Details
- Journal
- Journal of Clinical Virology
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1016/j.jcv.2025.105781
- Citations
- 2
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Francis Crick Institute
- University College London
- Manchester Biomedical Research Centre
- UCLH Biomedical Research Centre