Cyclic compression loading alters osteoarthritis-related gene expression in three-dimensionally cultured human articular chondrocytes via a different mechanism than interleukin-1β induction
Comprehensive gene expression analysis revealed that CCL-induced changes in gene expression were different to those induced by stimulation with IL-1β. Our results provide new insights into the involvement of mechanical stimulation in the pathogenesis of OA.
Authors
- Ken Nakata (ORCID: https://orcid.org/0000-0002-8964-4229)
- Kosuke Ebina (ORCID: https://orcid.org/0000-0002-2426-1024)
- Takashi Kanamoto (ORCID: https://orcid.org/0000-0001-6689-7277)
- Minami Hikida
- Masahiro Nakajima
- Yoshihito Tachi
Institutions
- Ajinomoto (Japan) (JP)
- Osaka Dental University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Journal of Oral Biosciences
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1016/j.job.2025.100653
- Citations
- 4
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.67
Funders
- Japan Society for the Promotion of Science