MG53 protects against septic cardiac dysfunction by ubiquitinating ATF2
MG53 protect the cardiac function against sepsis by down-regulation of TLR4 expression, via ubiquitination of ATF2, a TLR4 transcriptional factor, which might be a promising therapeutic approach for septic cardiac dysfunction.
Authors
- Jianjie Ma (ORCID: https://orcid.org/0000-0003-3865-6112)
- Wenjie Tan
- Yu Shi
- Peili Yang
- Xue Gong (ORCID: https://orcid.org/0000-0002-5847-7034)
- Miao Tian (ORCID: https://orcid.org/0000-0001-9086-1872)
- Xinyi Guo (ORCID: https://orcid.org/0009-0003-9794-0591)
- Gengze Wu (ORCID: https://orcid.org/0000-0002-1992-5308)
- Chunyu Zeng (ORCID: https://orcid.org/0009-0009-5059-2159)
- Qi Cai (ORCID: https://orcid.org/0009-0003-8777-311X)
- Yinghong Chen (ORCID: https://orcid.org/0000-0003-2208-4105)
- Hongmei Ren
Institutions
- Army Medical University (CN)
- Kunming Medical University (CN)
- Daping Hospital (CN)
- Lung Institute (US)
- Chongqing Emergency Medical Center (CN)
- The Ohio State University (US)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1016/j.jare.2025.03.031
- Citations
- 1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing