Periplakin Attenuates Liver Fibrosis via Reprogramming CD44Low Cells into CD44High Liver Progenitor Cells
These findings demonstrate that PPL<sup>+</sup>CD44<sup>Low</sup> cells can be reprogrammed into PPL<sup>+</sup>CD44<sup>High</sup> LPCs, which ameliorate liver fibrosis, suggesting a potential application of PPL for the treatment of liver fibrosis.
Authors
- Xi Sun (ORCID: https://orcid.org/0009-0004-7844-9753)
- Shurui Liu
- Jia Shen (ORCID: https://orcid.org/0000-0001-8994-3969)
- Zhongdao Wu (ORCID: https://orcid.org/0000-0001-5879-9757)
- Yunyi Hu (ORCID: https://orcid.org/0000-0002-8566-2745)
- Siyu Zhao (ORCID: https://orcid.org/0000-0003-3754-4354)
- Zebin Chen (ORCID: https://orcid.org/0000-0001-9582-6814)
- Zhiyong Xiong (ORCID: https://orcid.org/0000-0003-1894-7588)
- Meiyining Xu
- Lichao Zhang (ORCID: https://orcid.org/0000-0003-1811-7568)
- Xianzhi Liu (ORCID: https://orcid.org/0000-0002-6646-273X)
- Lifu Wang (ORCID: https://orcid.org/0000-0001-5172-9932)
- Kefeng Jiang
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Guangdong Provincial People's Hospital (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101498
- Citations
- 1
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.32