Minichromosome maintenance 4 plays a key role in protecting against acute kidney injury by regulating tubular epithelial cells survival and regeneration
These findings demonstrate that MCM4 upregulation during AKI development is an adaptive response that preserves tubular cell regenerative capacity and limits the severity of renal injury, thus highlighting the potential value of MCM4 as a biomarker or therapeutic target in patients with AKI.
Authors
- Huiling Xiang (ORCID: https://orcid.org/0000-0001-8827-234X)
- Chun Zhang (ORCID: https://orcid.org/0000-0003-3565-8024)
- Zhifeng Xu (ORCID: https://orcid.org/0000-0001-8968-0855)
- Qian Yuan (ORCID: https://orcid.org/0000-0002-3371-3336)
- Jing Huang (ORCID: https://orcid.org/0000-0003-3445-6164)
- Feng Liu (ORCID: https://orcid.org/0000-0002-5885-5015)
Institutions
- Union Hospital (HK)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1016/j.jare.2025.03.032
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Guangxi Key Research and Development Program