HyperSHArc: Single-Isocenter Stereotactic Radiosurgery of Multiple Brain Metastases Using Proton, Helium, and Carbon Ion Arc Therapy
We present the first particle arc therapy strategies for MBM. Results demonstrate that with HyperSHArc, dose conformity comparable or superior to HA-VMAT is achievable while reducing the low-dose bath and increasing mean dose-averaged linear energy transfer in the GTV. Our findings suggest that HyperSHArc using light and heavy ions could be an effective and efficient means of treating MBM. Further development of HyperSHArc optimization and delivery is justified.
Authors
- Lennart Volz (ORCID: https://orcid.org/0000-0003-0441-4350)
- Christian Graeff (ORCID: https://orcid.org/0000-0002-5296-7649)
- Peilin Liu (ORCID: https://orcid.org/0000-0002-5321-2336)
- Thomas Tessonnier (ORCID: https://orcid.org/0000-0002-8919-4299)
- Marco Durante (ORCID: https://orcid.org/0000-0002-4615-553X)
- Xuanfeng Ding (ORCID: https://orcid.org/0000-0002-1733-6278)
- Amir Abdollahi (ORCID: https://orcid.org/0000-0002-8016-5897)
- Stewart Mein (ORCID: https://orcid.org/0000-0002-6480-912X)
- Xiaoda Cong (ORCID: https://orcid.org/0009-0003-5175-630X)
- Taoran Li (ORCID: https://orcid.org/0000-0001-7180-4258)
- Andrea Mairani (ORCID: https://orcid.org/0000-0001-6669-7064)
- Wenbo Gu
Institutions
- GSI Helmholtz Centre for Heavy Ion Research (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Technische Universität Darmstadt (DE)
- Heidelberger Institut für Radioonkologie (DE)
- National Center for Oncological Hadrontherapy (IT)
- National Center for Tumor Diseases (DE)
- National Institutes for Quantum Science and Technology (JP)
- Yukhnovskii Institute for Condensed Matter Physics of the National Academy of Sciences of Ukraine (UA)
- Royal Oak Community Coalition (US)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- University of Pennsylvania (US)
Publication Details
- Journal
- Advances in Radiation Oncology
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1016/j.adro.2025.101763
- Citations
- 1
- Primary Topic
- Advanced Radiotherapy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- European Commission
- Horizon 2020