Triptolide Treatment for Oral Squamous Cell Carcinoma by Regulating the <scp>LncRNA</scp> ‐ <scp>MSTRG</scp> .24214.1/ <scp>MiRNA</scp> ‐939‐5p/ <scp>LCN2</scp> Axis
The lncRNA-miRNA-mRNA ceRNA network associated with triptolide's impact on OSCC was successfully established. Triptolide suppressed OSCC development and progression both in vitro and in vivo, potentially through modulation of the MSTRG.24214.1-miR-939-5p-LCN2 axis. These findings offer a solid foundation for future personalized triptolide-based therapeutic approaches.
Authors
- Yang Yu
- Siyan Chen (ORCID: https://orcid.org/0000-0001-6644-4729)
- Wuliji Saiyin (ORCID: https://orcid.org/0000-0001-9062-5028)
- Zhengmiao Li
- Jichen Li (ORCID: https://orcid.org/0000-0001-8599-1197)
- Bing Liu (ORCID: https://orcid.org/0000-0002-5974-1888)
- Menglin Hu
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Journal of Oral Pathology and Medicine
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1111/jop.13625
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94