Perivascular space and white matter hyperintensities in Alzheimer’s disease: associations with disease progression and cognitive function
This study highlights the potential of the DTI-ALPS-Index as a biomarker for glymphatic dysfunction in AD. It underscores the importance of considering vascular factors and the glymphatic system in the pathogenesis and diagnosis of AD as WMHs in the ROI could cause disturbances and inaccurate indices.
Authors
- Emrah Düzel (ORCID: https://orcid.org/0000-0002-0139-5388)
- Ayda Rostamzadeh (ORCID: https://orcid.org/0000-0001-5189-134X)
- Robert Forbrig (ORCID: https://orcid.org/0000-0002-1054-1463)
- Robert Perneczky (ORCID: https://orcid.org/0000-0003-1981-7435)
- Ersin Ersoezlue (ORCID: https://orcid.org/0000-0001-6503-5894)
- Oliver Peters (ORCID: https://orcid.org/0000-0003-0568-2998)
- Michael Ewers (ORCID: https://orcid.org/0000-0003-1856-9337)
- Selim Guersel
- Boris‐Stephan Rauchmann (ORCID: https://orcid.org/0000-0003-4547-6240)
- Toshiaki Taoka (ORCID: https://orcid.org/0000-0001-9227-0240)
- Katharina Büerger (ORCID: https://orcid.org/0000-0002-5898-9953)
- Klaus Fließbach (ORCID: https://orcid.org/0000-0002-0183-7510)
- Josef Priller (ORCID: https://orcid.org/0000-0001-7596-0979)
- Adriana L. Ruiz‐Rizzo (ORCID: https://orcid.org/0000-0003-1467-0745)
- Carolin Kurz (ORCID: https://orcid.org/0000-0003-4299-6240)
- Daniel Janowitz (ORCID: https://orcid.org/0009-0003-4090-547X)
- Ingo Kilimann (ORCID: https://orcid.org/0000-0002-3269-4452)
- Julian Hellmann‐Regen (ORCID: https://orcid.org/0000-0003-0411-9204)
- Anja Schneider (ORCID: https://orcid.org/0000-0001-9540-8700)
- Wenzel Glanz (ORCID: https://orcid.org/0000-0002-5865-4176)
- Eike Spruth
- Philine Marie Schirge
- Sebastian Sodenkamp
- Matthias Brendel
- Christoph Laske
- Stefan Teipel
- Frank Jessen
Institutions
- University of Cologne (DE)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Munich Cluster for Systems Neurology (DE)
- Jena University Hospital (DE)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- MRC Unit for Lifelong Health and Ageing (GB)
- Hertie Institute for Clinical Brain Research (DE)
- The London College (GB)
- University of Rostock (DE)
- Nagoya University (JP)
- Technical University of Munich (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- University of Sheffield (GB)
- Otto-von-Guericke-Universität Magdeburg (DE)
- University of Edinburgh (GB)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s13195-025-01707-9
- Citations
- 18
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 16.36