Association between early-phase opioid use and outcomes in extremely preterm infants: A nationwide study
This large retrospective nationwide study of 13,988 extremely preterm infants revealed that using early-phase opioids was not significantly associated with in-hospital mortality or intraventricular hemorrhage but was significantly associated with a decrease in periventricular leukomalacia. Early-phase opioids may not increase mortality or intraventricular hemorrhage, in contrast to the results of previous studies. Thus, these results could help clinicians select opioids as sedative agents for extremely preterm infants.
Authors
- Hiroki Kitaoka (ORCID: https://orcid.org/0000-0003-0958-5028)
- Yoshihiko Shitara (ORCID: https://orcid.org/0000-0001-7449-3838)
- Yuya Kimura (ORCID: https://orcid.org/0000-0003-1649-0596)
- Atsushi Ito (ORCID: https://orcid.org/0000-0003-3482-2742)
- Kohei Kashima (ORCID: https://orcid.org/0000-0002-8727-7613)
- Hideo Yasunaga (ORCID: https://orcid.org/0000-0002-6017-469X)
- Motohiro Kato (ORCID: https://orcid.org/0000-0001-5145-1774)
- Takaaki Konishi (ORCID: https://orcid.org/0000-0002-9538-4419)
- Hiroki Matsui (ORCID: https://orcid.org/0000-0002-9605-442X)
- Naoto Takahashi (ORCID: https://orcid.org/0000-0003-3749-5871)
Institutions
- Tokyo Women's Medical University Hospital (JP)
- University of Tokyo Hospital (JP)
- University of Tokyo Health Sciences (JP)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1038/s41390-025-03998-y
- Citations
- 2
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Ministry of Health, Labour and Welfare
- University of Tokyo