Proteomic analysis of premature umbilical cord blood and its relationship with bronchopulmonary dysplasia
Our findings suggest that the development of BPD is associated with changes in the plasma proteome of preterm infants. Specifically, the levels of AOC3 and H4C6 in the bloodstream could serve as biomarkers for the early detection of BPD in preterm infants. Furthermore, we found that GOLM1, lipopolysaccharide (LPS)-binding protein, XRCC6, and the contribution of neutrophil degranulation may play a crucial role in the development of therapies for BPD.
Authors
- Zhiwei Guo (ORCID: https://orcid.org/0000-0002-0981-6423)
- Longli Yan
- Ying Liu (ORCID: https://orcid.org/0000-0002-8997-2257)
- Jia Chen (ORCID: https://orcid.org/0000-0002-4242-2899)
- Yang He (ORCID: https://orcid.org/0009-0004-9183-818X)
- Weiwei Gao (ORCID: https://orcid.org/0000-0002-1451-3312)
- Xiaotao Jiang (ORCID: https://orcid.org/0000-0002-4519-4289)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangzhou First People's Hospital (CN)
- Guangdong Province Women and Children Hospital (CN)
- Guangdong Provincial People's Hospital (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- The Italian Journal of Pediatrics/Italian journal of pediatrics
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1186/s13052-025-01926-8
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00