Comparison of in-vitro immunomodulatory capacity between large and small apoptotic bodies from human bone marrow mesenchymal stromal cells
Staurosporine-induced ApoBDs are non-cytotoxic and exhibit significant immunomodulatory potential in vitro. Large ApoBDs are more effective than small ApoBDs in T-cell suppression and M2 macrophage polarization, suggesting their potential as an alternative to MSC-based therapies in future studies.
Authors
- Manon Jammes
- Aideen E. Ryan (ORCID: https://orcid.org/0000-0002-5831-6783)
- Thorsten Bach (ORCID: https://orcid.org/0000-0002-3734-7484)
- Seyedmohammad Moosavizadeh (ORCID: https://orcid.org/0000-0001-7414-3248)
- Thomas Ritter (ORCID: https://orcid.org/0000-0001-7709-8489)
- Jiemin Wang (ORCID: https://orcid.org/0000-0003-3285-5663)
- Abbas Tabasi
Institutions
- Ollscoil na Gaillimhe – University of Galway (IE)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1016/j.intimp.2025.114480
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- European Commission
- Science Foundation Ireland
- China Scholarship Council
- HORIZON EUROPE Framework Programme
- European Regional Development Fund