Silybin loaded Ag‐nanoparticles as a drug delivery system for solid tumor theragnosis: Extraction, radioiodination, and biodistribution study
Biocompatible silver nanoparticles (AgNPs) are employed with an active ingredient of milk thistle extract, silybin (SIB), to treat cancers. Strong cytotoxic effects of SIB-AgNPs against two distinct cell lines (MCF-7 and HepG2) are observed on a stable nano-platform that contains spherical nanoparticles within a limited size range. With a high radiochemical purity, radioiodination of SIB-AgNPs was accomplished. The investigation on the biodistribution of [<sup>131</sup>I]iodo-SIB-AgNPs in mice-bearing tumors showed that SIB-AgNPs prefer localization in tumor tissue. In conclusion, this work strengthens the case for [<sup>131</sup>I]iodo-SIB-AgNPs as an effective theranostic agent for tumor imaging and treatment.
Authors
- Adli A. Selim (ORCID: https://orcid.org/0000-0001-7095-5978)
- Basma M. Essa (ORCID: https://orcid.org/0000-0002-3141-9918)
- Mohamed A. Amin (ORCID: https://orcid.org/0000-0002-1329-9596)
- Islam M. Abdelmonem (ORCID: https://orcid.org/0000-0002-0760-4451)
Institutions
- Egyptian Atomic Energy Authority (EG)
Publication Details
- Journal
- Archiv der Pharmazie
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/ardp.202400725
- Citations
- 2
- Primary Topic
- Silymarin and Mushroom Poisoning
- Type
- article
- Field-Weighted Citation Impact
- 3.04