Unraveling the Dual Role of circ‐<scp>CBLB</scp> and <scp>ETS</scp>‐1 in Rheumatoid Arthritis: Biomarkers and Therapeutic Targets
circ-CBLB and ETS-1 are downregulated in RA and correlate with inflammation and disease activity. They regulate each other bidirectionally. circ-CBLB reduces RA-FLS viability, promotes apoptosis, and inhibits migration by modulating cytokines. ETS-1 has similar effects, and interfering with its expression reverses the impact of circ-CBLB.
Authors
- Lei Wan (ORCID: https://orcid.org/0000-0002-9525-3232)
- Xiaojun Zhang (ORCID: https://orcid.org/0000-0002-0304-0003)
- Hongwei Fang (ORCID: https://orcid.org/0000-0001-5577-4044)
- Shu Li (ORCID: https://orcid.org/0000-0002-2028-2805)
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- International Journal of Rheumatic Diseases
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1111/1756-185x.70167
- Citations
- 3
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China