Anti-MRSA and cytotoxic activity of a new diamide compound isolated from <i>Aspergillus</i> sp. H30
A new aromatic diamide compound, aspergillusin A (<b>1</b>), together with three known compounds, globosterol (<b>2</b>), ergosterol (<b>3</b>), and cladosporide A (<b>4</b>), was isolated from the crude extract of the endophytic fungi <i>Aspergillus</i> sp. H30. The structures were elucidated using NMR and MS data, finally, the biosynthetic pathway of compound <b>1</b> was hypothesised. Compounds <b>1</b>-<b>4</b> were tested for their antibacterial activities on six pathogenic bacteria and compound <b>1</b> was also evaluated against human non-small cell lung cancer H1299. Among them, compound <b>1</b> exhibited weak antibacterial activity against MRSA and a strong effect against the human bronchial epithelial cell line, BEAS-2B, with an IC<sub>50</sub> value of 12.32 ± 0.37 <i>μ</i>M.
Authors
- Qiao-Ni Chen
- Yingying Hu (ORCID: https://orcid.org/0000-0001-9970-7986)
- Long-Fen Li
- Xuekui Xia (ORCID: https://orcid.org/0000-0001-9673-2828)
- Xinzhu Wang (ORCID: https://orcid.org/0000-0002-9469-436X)
- Peipei Zhao (ORCID: https://orcid.org/0000-0002-0475-9554)
- Qing-Zhou Meng
- Ying Xu (ORCID: https://orcid.org/0000-0002-4210-468X)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Qilu University of Technology (CN)
- Shandong Academy of Sciences (CN)
- Guangdong Ocean University (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1080/14786419.2025.2478529
- Citations
- 1
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.39